Our newest research paper, entitled “Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03“, was selected as the American Chemical Society (ACS) Editors’ Choice for March 27, 2015.
The paper describes a detailed investigation of the interaction of amyloid β-protein (Aβ), the protein believed to cause Alzheimer’s disease, with the molecular tweezer, CLR01, and the negative-control derivative CLR03. Previously, CLR01 was found to be an effective inhibitor of Aβ aggregation and toxicity in test-tube experiments, cell culture, and animal models. The new study showed that upon interaction with Aβ, CLR01 reduces the concentration of specific structures and essentially eliminates structures believed to be particularly harmful, which are made of 6 and 12 units of Aβ.
The study was conducted primarily by Xueyun Zheng, a graduate student in the group of Professor Michael Bowers at the University of California, Santa Barbara, and was published in the Journal of Physical Chemistry B.
ACS Editor’s Choice articles are selected from among the over 60 publications of the ACS. With ACS Editors’ Choice, ACS offers free public access to new research of importance to the global scientific community. These peer-reviewed, open access articles consist of research that exemplifies the Society’s commitment to improving people’s lives through the transforming power of chemistry. The selection of these articles is based on recommendations by the scientific editors of ACS journals from around the world. To date, only 7 papers from the Journal of Physical Chemistry B received this honor.