1. F-G Klärner, J Benkhoff, R Boese, U Burkert, M Kamieth, and U Naatz. Molecular Tweezers as Synthetic Receptors in Host-Guest Chemistry: Inclusion of Cyclohexane and Self-Assembly of Aliphatic Side Chains. Angew. Chem. Int. Ed. Engl. 1996; 35: 1130-1133.
  2. M Kamieth, F-G Klärner, and F Diederich. Modeling the Supramolecular Properties of Aliphatic-Aromatic Hydrocarbons with Convex-Concave Topology. Angew. Chem. Int. Ed. 1998; 37: 3303-3306.
  3. F-G Klärner, U Burkert, M Kamieth, R Boese, and J Benet-Buchholz. Molecular Tweezers as Synthetic Receptors: Molecular Recognition of Elec­tron-Deficient Aromatic and Aliphatic Substrates. Chem. Eur. J. 1999; 5: 1700-1707.
  4. F-G Klärner, J Panitzky, D Preda, and LT Scott. Modeling of Supramolecular Properties of Molecular Tweezers, Clips, and Bowls. J. Mol. Model. 2000; 6: 318-327.
  5. FG Klärner, J Panitzky, D Bläser, R Boese. Syntheses and Supramolecular Structures of Molecular Clips. Tetrahedron 2001; 3673-3687.
  6. C Jasper, T Schrader, J Panitzky, and F-G Klärner. Selective Complexation of N-Alkylpyridinium Salts: Recognition of NAD+ in Water. Angew. Chem. Int. Ed. 2002; 41: 1355-1358.
  7. F-G Klärner and B Kahlert. Molecular tweezers and clips as synthetic receptors. Molecular recognition and dynamics in receptor-substrate complexes. Acc. Chem. Res. 2003; 36: 919-932.
  8. M Fokkens, C Jasper C, T Schrader, F Koziol, C Ochsenfeld, J Polkowska, M Lobert, B Kahlert, and F-G Klärner. Selective complexation of N-alkylpyridinium salts: binding of NAD+ in water. Chem. Eur. J. 2005; 11: 477-494.
  9. M Fokkens, T Schrader, and F-G Klärner. A molecular tweezer for lysine and arginine. J. Am. Chem. Soc. 2005; 127: 14415-14421.
  10. F-G Klärner, B Kahlert, A Nellesen, J Zienau, C Ochsenfeld, and T Schrader. Molecular tweezer and clip in aqueous solution: Unexpected self-assembly, powerful host-guest complex formation, quantum chemical H-1 NMR shift calculation. J. Am. Chem. Soc. 2006; 128: 4831-4841. Additions and corrections – J. Am. Chem. Soc. 2010; 132: 4029.
  11. P Talbiersky, F Bastkowski, F-G Klärner, and T Schrader. Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition. J. Am. Chem. Soc. 2008; 30: 9824–9828,
  12. J Polkowska, F Bastkowski, T Schrader, F-G Klärner, J Zienau, F Koziol, and C Ochsenfeld. A combined experimental and theoretical study of the pH-dependent binding mode of NAD+ by water-soluble molecular clips. J. Phys. Org. Chem. 2009; 22, 779–790.
  13. M Kirsch, P Talbiersky, J Polkowska, F Bastkowski, T Schaller, H de Groot, F-G Klärner, and T Schrader. A Mechanism of Efficient G6PD Inhibition by a Molecular Clip. Angew. Chem. Int. Ed. 2009; 48: 2886-2890,
  14. S Sinha, DHJ Lopes, Z Du, ES Pang, A Shanmugam, A Lomakin, P Talbiersky, A Tennstaedt, K McDaniel, R Bakshi, P-Y Kuo, M Ehrmann, GB Benedek, JA Loo, F-G Klärner, T Schrader, C Wang, and G Bitan. Lysine-specific molecular tweezers are broad-spectrum inhibitor of aggregation and toxicity of amyloid proteins. J. Am. Chem. Soc. 2011; 133(42): 16958–16969.
  15. S Sinha, Z Du, P Maiti, F-G Klärner, T Schrader, C Wang, and G Bitan. Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01. ACS Chem. Neurosci. 2012; 3(6): 451-458.
  16. S Sinha, DHJ Lopes, and G Bitan. A Key Role for Lysine Residues in Amyloid β-Protein Folding, Assembly, and Toxicity. ACS Chem. Neurosci. 2012; 3(6): 473-481.
  17. S Prabhudesai*, S Sinha*, A Attar, A Kotagiri, AG Fitzmaurice, R Lakshmanan, MI Ivanova, JA Loo, F-G Klärner, T Schrader, M Stahl, G Bitan#, and JM Bronstein#. A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo. Neurotherapeutics. 2012; 9(2): 464-476.
  18. T Liu and G Bitan. Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms. ChemMedChem. 2012; 7: 359-374.
  19. A Attar, C Ripoli, E Riccardi, P Maiti, DD Li Puma, T Liu, J Hayes, MR Jones, K Lichti-Kaiser, F Yang, GD Gale, C-h Tseng, M Tan, C-W Xie, JL Straudinger, F-G Klärner, T Schrader, SA Frautschy, C Grassi and G Bitan. Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers. Brain. 2012; 135(Pt 12): 3735-3748.
  20. F-G Klärner and T Schrader. Aromatic Interactions by Molecular Tweezers and Clips in Chemical and Biological Systems. Acc. Chem. Res. 2013; 46: 967-978.
  21. S Dutt, C Wilch, T Gersthagen, P Talbiersky, K Bravo-Rodriguez, M Hanni, E Sánchez-García, C Ochsenfeld, F-G Klärner, and T Schrader. Molecular Tweezers with Varying Anions – A Comparative Study. J. Org. Chem. 2013; 78 (13): 6721–6734.
  22. D Bier, R Rose, K Bravo-Rodriguez, M Bartel, JM Ramirez-Anguita, S Dutt, C Wilch, F -G Klärner, E Sanchez-Garcia, T Schrader, and C Ottmann. Molecular tweezers modulate 14-3-3 protein–protein interactions. Nat. Chem. 2013; 5: 234–239,
  23. A Attar, F Rahimi, and G Bitan. Modulators of amyloid protein aggregation and toxicity: EGCG and CLR01. Translational Neuroscience. 2013; 4(4): 385-409.
  24. S Acharya, BM Safaie, P Wongkongkathep, MI Ivanova, A Attar, F-G Klärner, T Schrader, JA Loo, G Bitan, and LJ Lapidus. Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer. J. Biol. Chem. 2014; 289(15): 10727-10737.
  25. N Ferreira, A Pereira-Henriques, A Attar, F-G Klärner, T Schrader, G Bitan, L Gales, MJ Saraiva, and MR Almeida. Molecular Tweezers Targeting Transthyretin Amyloidosis. Neurotherapeutics. 2014; 11: 450-461.
  26. A Attar, W-TC Chan, F-G Klärner, T Schrader, and G Bitan. Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity. BMC Pharm. Tox. 2014; 15(23): doi:10.1186/2050-6511-15-23.
  27. A Attar and G Bitan. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by ” molecular tweezers” – from the test tube to animal models, Curr. Pharm. Des. 2014; 20: 2469-2483.
  28. X Zheng, D-Y Liu, F-G Klärner, T Schrader, G Bitan, and MT Bowers. Amyloid β-protein Assembly: The Effect of Molecular Tweezer CLR01 and CLR03. J. Phys. Chem. B, 2015; 119: 4831-4841.
  29. DHJ Lopes, A Attar, G Nair, EY Hayden, Z Du, K McDaniel, S Dutt, K Bravo-Rodriguez, S Mittal, F-G Klärner, C Wang, E Sanchez-Garcia, T Schrader, and G Bitan (2015) Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism, ACS Chem. Biol. 2015; 10: 1555-1569.
  30. G Herzog, MD Shmueli, L Levi, L Engel, E Gazit, F-G Klärner, T Schrader, G Bitan, and D Segal. The Lys-specific molecular tweezer, CLR01, modulates aggregation of mutant p53 DNA binding domain and inhibits its toxicity, Biochemistry, 2015; 54: 3729–3738. Feature in the Spotlight of ACS Chemical Research in Toxicology.
  31. E Lump, LM Castellano, C Meier, J Seeliger, N Erwin, B Sperlich, CM Stürzel, S Usmani, RM Hammond, J von Einem, G Gerold, F Kreppel, K Bravo-Rodriguez, T Pietschmann, VM Holmes, D Palesch, O Zirafi, D Weissman, A Sowislok, B Wettig, C Heid, F Kirchhoff, T Weil, F-G Klärner, T Schrader, G Bitan, E Sanchez-Garcia, R Winter, J Shorter, and Jan Münch, A molecular tweezer antagonizes seminal amyloids and HIV infection, eLife, 2015; 4:e05397.
  32. R Malishev, S Nandi, S Kolusheva, Y Levi-Kalisman, F-G Klärner, T Schrader, G Bitan*, and R Jelinek*, Toxicity inhibitors protect lipid membranes from disruption by Aβ42, ACS Chem. Neurosci. 2015; 6: 1860-1869.
  33. SM Fogerson, AJ van Brummen, DJ Busch, SR Allen, R Roychaudhuri, S Banks, F-G Klärner, T Schrader, G Bitan, and JR Morgan, Reducing synuclein accumulation improves neuronal survival after spinal cord injury, Exp. Neurol. 2016; 278: 105-115.
  34. A Lulla, L Barnhill, G Bitan, MI Ivanova, B Nguyen, K O’Donnell, MC Stahl, C Yamashiro, F-G Klärner, T Schrader, A Sagasti, and JM Bronstein, Environ. Health Perspect. 2016; 124: 1766-1775.
  35. T Schrader, G Bitan, and F-G Klärner, Molecular Tweezers for Lysine and Arginine – Powerful Inhibitors of Pathologic Protein Aggregation, Chem. Commun. 2016; 52: 11318-11334.
  36. T Vöpel, K Bravo-Rodriguez, S Mittal, S Vachharajani, D Gnutt, A Sharma, A Steinhoff, F Oluwaseun, G Ellrichmann, N Nshinian, C Heid, JA Loo, F-G Klärner, T Schrader, G Bitan, EE Wanker, S Ebbinghaus, and E Sanchez-Garcia, Inhibition of Huntingtin aggregation by the molecular tweezer CLR01. J. Am. Chem. Soc., 2017; 139: 5640–5643.
  37. F Richter, SR Subramaniam, I Magen, P Lee, J Hayes, A Attar, C Zhu, NR Franich, N Bove, K de la Rosa, J Kwong, F-G Klärner, T Schrader, M-F Chesselet, and G Bitan, A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein. Neurotherapeutics2017; 14: 1107-1119.
  38. N Xu, G Bitan, T Schrader, F-G Klärner, H Osinska, and J Robbins (2017) Inhibition of mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer. J. Am. Heart Assoc. 2017.
  39. AE Röcker, JA.Müller, E Dietzel, M Harms, F Krüger, C Heid, A Sowisolk, C Frich-Riber, A Kupke, S Lippold, J von Einem, J Beer, B Knöll, S Becker, J Schmidt-Chanasit, M Otto, O Vapalahti, AN Zelikin, G Bitan, T Schrader and J Münch (2018) The molecular tweezer CLR01 inhibits Ebola and Zika Virus infection. Antiviral Res., e-pub ahead of print, DOI 10.1016/j.antiviral.2018.02.003.