Nadia Stefanova, M.D., Ph.D.
Medical University of Innsbruck
Nadia Stefanova received her medical degree from the Medical University of Sofia, Bulgaria, and the University of Innsbruck, Austria. She went on to complete a Ph.D. in Neuroscience. Dr. Stefanova joined the Department of Neurology in the University of Innsbruck where she performed her post-doctoral studies in Experimental Neurology, became an Assistant Professor in 2006, and was promoted to Associate Professor in 2011. Dr. Stefanova leads the Laboratory for Neurodegenerative Disease Research at the Department of Neurology, Medical University of Innsbruck. Her research focuses on the development and characterization of experimental models of multiple systems atrophy (MSA) and their utilization in target development and preclinical therapeutic screening. The MSA-devoted studies of Dr. Stefanova address the implication of ectopic oligodendroglial aggregation of α-synuclein and neuroinflammatory responses in mechanisms that compromise neuronal viability in MSA.
Investigation of the molecular tweezer CLR01 in pre-clinical models of Multiple Systems Atrophy.
Our group, in collaboration with the Bitan group, is testing preclinically the effects of molecular tweezers as a therapeutic option for MSA, targeting α-synuclein pathology in this devastating disorder. The study, which is supported by grants from the MSA Coalition, uses the PLP-aSyn mouse model that has been characterized thoroughly by our group. Initial, promising results from the study were presented at the AD/PD Conference in Vienna, Austria, in April 2017.